Vitamin D and the Epithelial to Mesenchymal Transition
Joint Authors
Larriba, María Jesús
García de Herreros, Antonio
Muñoz, Alberto
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Several studies support reciprocal regulation between the active vitamin D derivative 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) and the epithelial to mesenchymal transition (EMT).
Thus, 1,25(OH)2D3 inhibits EMT via the induction of a variety of target genes that encode cell adhesion and polarity proteins responsible for the epithelial phenotype and through the repression of key EMT inducers.
Both direct and indirect regulatory mechanisms mediate these effects.
Conversely, certain master EMT inducers inhibit 1,25(OH)2D3 action by repressing the transcription of V D R gene encoding the high affinity vitamin D receptor that mediates 1,25(OH)2D3 effects.
Consequently, the balance between the strength of 1,25(OH)2D3 signaling and the induction of EMT defines the cellular phenotype in each context.
Here we review the current understanding of the genes and mechanisms involved in the interplay between 1,25(OH)2D3 and EMT.
American Psychological Association (APA)
Larriba, María Jesús& García de Herreros, Antonio & Muñoz, Alberto. 2016. Vitamin D and the Epithelial to Mesenchymal Transition. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116898
Modern Language Association (MLA)
Larriba, María Jesús…[et al.]. Vitamin D and the Epithelial to Mesenchymal Transition. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116898
American Medical Association (AMA)
Larriba, María Jesús& García de Herreros, Antonio & Muñoz, Alberto. Vitamin D and the Epithelial to Mesenchymal Transition. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116898