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Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging
Joint Authors
Verfaillie, Catherine M.
Gheysens, Olivier
Sampaolesi, Maurilio
Quattrocelli, Mattia
Holvoet, Bryan
De Waele, Liesbeth
Deroose, Christophe M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-22
Country of Publication
Egypt
No. of Pages
20
Abstract EN
Numerous neurodegenerative and neuromuscular disorders are associated with cell-specific depletion in the human body.
This imbalance in tissue homeostasis is in healthy individuals repaired by the presence of endogenous stem cells that can replace the lost cell type.
However, in most disorders, a genetic origin or limited presence or exhaustion of stem cells impairs correct cell replacement.
During the last 30 years, methods to readily isolate and expand stem cells have been developed and this resulted in a major change in the regenerative medicine field as it generates sufficient amount of cells for human transplantation applications.
Furthermore, stem cells have been shown to release cytokines with beneficial effects for several diseases.
At present however, clinical stem cell transplantations studies are struggling to demonstrate clinical efficacy despite promising preclinical results.
Therefore, to allow stem cell therapy to achieve its full potential, more insight in their in vivo behavior has to be achieved.
Different methods to noninvasively monitor these cells have been developed and are discussed.
In some cases, stem cell monitoring even reached the clinical setting.
We anticipate that by further exploring these imaging possibilities and unraveling their in vivo behavior further improvement in stem cell transplantations will be achieved.
American Psychological Association (APA)
Holvoet, Bryan& De Waele, Liesbeth& Quattrocelli, Mattia& Gheysens, Olivier& Sampaolesi, Maurilio& Verfaillie, Catherine M.…[et al.]. 2016. Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging. Stem Cells International،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1116900
Modern Language Association (MLA)
Holvoet, Bryan…[et al.]. Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1116900
American Medical Association (AMA)
Holvoet, Bryan& De Waele, Liesbeth& Quattrocelli, Mattia& Gheysens, Olivier& Sampaolesi, Maurilio& Verfaillie, Catherine M.…[et al.]. Increased Understanding of Stem Cell Behavior in Neurodegenerative and Neuromuscular Disorders by Use of Noninvasive Cell Imaging. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1116900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116900