The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
In principle, induced pluripotent stem cells (iPSCs) are generated from somatic cells by reprogramming and gaining the capacity to self-renew indefinitely as well as the ability to differentiate into cells of different lineages.
Human iPSCs have absolute advantages over human embryonic stem cells (ESCs) and animal models in disease modeling, drug screening, and cell replacement therapy.
Since Takahashi and Yamanaka first described in 2007 that iPSCs can be generated from human adult somatic cells by retroviral transduction of the four transcription factors, Oct3/4, Sox2, Klf4, and c-Myc, disease specific iPSC lines have sprung up worldwide like bamboo shoots after a spring rain, making iPSC one of the hottest and fastest moving topics in modern science.
The craze for iPSCs has spread throughout main branches of clinical medicine, covering neurology, hematology, cardiology, endocrinology, hepatology, ophthalmology, and so on.
Here in this paper, we will focus on the clinical application of human iPSCs in disease modeling, drug screening, and cell replacement therapy for neurological diseases.
American Psychological Association (APA)
Xie, Nina& Tang, Bei-sha. 2016. The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116932
Modern Language Association (MLA)
Xie, Nina& Tang, Bei-sha. The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116932
American Medical Association (AMA)
Xie, Nina& Tang, Bei-sha. The Application of Human iPSCs in Neurological Diseases: From Bench to Bedside. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116932
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116932