Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma
Joint Authors
Lee, Su-Jae
Huh, Yong-Min
Hong, Yong-Kil
Moon, Ju Hyung
Shim, Jin-Kyoung
Lee, Ji-Hyun
Kim, Eui-Hyun
Chang, Jong Hee
Kim, Sun Ho
Kang, Seok-Gu
Yoon, Seon-Jin
Roh, Tae-Hoon
Sung, Kyoung Su
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-11
Country of Publication
Egypt
No. of Pages
7
Abstract EN
The isolation from brain tumors of tumor mesenchymal stem-like cells (tMSLCs) suggests that these cells play a role in creating a microenvironment for tumor initiation and progression.
The clinical characteristics of patients with primary glioblastoma (pGBM) positive for tMSLCs have not been determined.
This study analyzed samples from 82 patients with pGBM who had undergone tumor removal, pathological diagnosis, and isolation of tMSLC from April 2009 to October 2014.
Survival, extent of resection, molecular markers, and tMSLC culture results were statistically evaluated.
Median overall survival was 18.6 months, 15.0 months in tMSLC-positive patients and 29.5 months in tMSLC-negative patients (P=0.014).
Multivariate cox regression model showed isolation of tMSLC (OR = 2.5, 95% CI = 1.1~5.6, P=0.021) showed poor outcome while larger extent of resection (OR = 0.5, 95% CI = 0.2~0.8, P=0.011) has association with better outcome.
The presence of tMSLCs isolated from the specimen of pGBM is associated with the survival of patient.
American Psychological Association (APA)
Yoon, Seon-Jin& Shim, Jin-Kyoung& Chang, Jong Hee& Moon, Ju Hyung& Roh, Tae-Hoon& Sung, Kyoung Su…[et al.]. 2016. Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116962
Modern Language Association (MLA)
Yoon, Seon-Jin…[et al.]. Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1116962
American Medical Association (AMA)
Yoon, Seon-Jin& Shim, Jin-Kyoung& Chang, Jong Hee& Moon, Ju Hyung& Roh, Tae-Hoon& Sung, Kyoung Su…[et al.]. Tumor Mesenchymal Stem-Like Cell as a Prognostic Marker in Primary Glioblastoma. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116962
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116962