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TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells
Joint Authors
Linta, Leonhard
Raab, Stefanie
Klingenstein, Moritz
Achberger, Kevin
Liebau, Stefan
Kleger, Alexander
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
7
Abstract EN
TBX3 is a member of the T-box transcription factor family and is involved in the core pluripotency network.
Despite this role in the pluripotency network, its contribution to the reprogramming process during the generation of human induced pluripotent stem cells remains elusive.
In this respect, we performed reprogramming experiments applying TBX3 knockdown in human fibroblasts and keratinocytes.
Knockdown of TBX3 in both somatic cell types decreased the reprogramming efficiencies in comparison to control cells but with unchanged reprogramming kinetics.
The resulting iPSCs were indistinguishable from control cells and displayed a normal in vitro differentiation capacity by generating cells of all three germ layers comparable to the controls.
American Psychological Association (APA)
Klingenstein, Moritz& Raab, Stefanie& Achberger, Kevin& Kleger, Alexander& Liebau, Stefan& Linta, Leonhard. 2015. TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116964
Modern Language Association (MLA)
Klingenstein, Moritz…[et al.]. TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1116964
American Medical Association (AMA)
Klingenstein, Moritz& Raab, Stefanie& Achberger, Kevin& Kleger, Alexander& Liebau, Stefan& Linta, Leonhard. TBX3 Knockdown Decreases Reprogramming Efficiency of Human Cells. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116964