![](/images/graphics-bg.png)
Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury
Joint Authors
Kakabadze, Zurab
Kipshidze, Nickolas
Mardaleishvili, Konstantine
Chutkerashvili, Gocha
Chelishvili, Irakli
Harders, Albrecht
Loladze, George
Shatirishvili, Gocha
Kipshidze, Nodar
Chakhunashvili, David
Chutkerashvili, Konstantine
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-05
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Introduction.
A total of 18 patients, with complete motor deficits and paraplegia caused by thoracic and lumbar spine trauma without muscle atrophy or psychiatric problems, were included into this study.
Materials and Methods.
The bone marrow was aspirated from the anterior iliac crest under local anesthesia and the mononuclear fraction was isolated by density gradient method.
At least 750 million mononuclear-enriched cells, suspended in 2 mL of saline, were infused intrathecally.
Results and Discussion.
The study reports demonstrated improvement of motor and sensory functions of various degrees observed in 9 of the 18 (50%) cases after bone marrow stem cell transplantation.
Measured by the American Spinal Injury Association (ASIA) scale, 7 (78%) out of the 9 patients observed an improvement by one grade, while two cases (22%) saw an improvement by two grades.
However, there were no cases in which the condition was improved by three grades.
Conclusions.
Analysis of subsequent treatment results indicated that the transplantation of mononuclear-enriched autologous BMSCs is a feasible and safe technique.
However, successful application of the BMSCs in the clinical practice is associated with the necessity of executing more detailed examinations to evaluate the effect of BMSCs on the patients with spinal cord injury.
American Psychological Association (APA)
Kakabadze, Zurab& Kipshidze, Nickolas& Mardaleishvili, Konstantine& Chutkerashvili, Gocha& Chelishvili, Irakli& Harders, Albrecht…[et al.]. 2016. Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116966
Modern Language Association (MLA)
Kakabadze, Zurab…[et al.]. Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116966
American Medical Association (AMA)
Kakabadze, Zurab& Kipshidze, Nickolas& Mardaleishvili, Konstantine& Chutkerashvili, Gocha& Chelishvili, Irakli& Harders, Albrecht…[et al.]. Phase 1 Trial of Autologous Bone Marrow Stem Cell Transplantation in Patients with Spinal Cord Injury. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116966
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116966