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Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in XenoSerum-Free Condition: In Vitro and In Vivo Assessment
Joint Authors
Hyun, Jung Keun
Jung, Jieun
Kim, Jong-Wan
Moon, Ho-Jin
Hong, Jin Young
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-05
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Neural stem cells (NSCs) have a high potency for differentiation to neurons and glial cells for replacement of damaged cells and paracrine effects for the regeneration and remyelination of host axons.
Dental pulp is known to have a potential to differentiate into neural-like cells; therefore, dental pulp may be used as an autologous cell source for neural repair.
In this study, we selectively expanded stem cells from human dental pulp in an initial culture using NSC media under xeno- and serum-free conditions.
At the initial step of primary culture, human dental pulp was divided into two groups according to the culture media: 10% fetal bovine serum medium group (FBS group) and NSC culture medium group (NSC group).
In the NSC group relative to the FBS group, the expression of NSC markers and the concentrations of leukemia inhibitory factor, nerve growth factor, and stem cell factor were higher, although their expression levels were lower than those of human fetal NSCs.
The transplanted cells of the NSC group survived well within the normal brain and injured spinal cord of rats and expressed nestin and Sox2.
Under the xeno- and serum-free conditions, autologous human dental pulp-derived stem cells might prove useful for clinical cell-based therapies to repair damaged neural tissues.
American Psychological Association (APA)
Jung, Jieun& Kim, Jong-Wan& Moon, Ho-Jin& Hong, Jin Young& Hyun, Jung Keun. 2016. Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in XenoSerum-Free Condition: In Vitro and In Vivo Assessment. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116990
Modern Language Association (MLA)
Jung, Jieun…[et al.]. Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in XenoSerum-Free Condition: In Vitro and In Vivo Assessment. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116990
American Medical Association (AMA)
Jung, Jieun& Kim, Jong-Wan& Moon, Ho-Jin& Hong, Jin Young& Hyun, Jung Keun. Characterization of Neurogenic Potential of Dental Pulp Stem Cells Cultured in XenoSerum-Free Condition: In Vitro and In Vivo Assessment. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116990