Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease
Joint Authors
Zhao, Chen
Yang, Shuai
Hu, Xiao-Ying
Lian, Weishuai
Lou, Wensheng
Han, Shilong
Lu, Chenhui
Xu, Jichong
Cao, Chuanwu
Tang, Tao
Jia, Zhongzhi
Uzan, Georges
Gu, Jianping
Li, Maoquan
Guang-Xing, Chen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-14
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Microvascular lesion in diabetic peripheral arterial disease (PAD) still cannot be resolved by current surgical and interventional technique.
Endothelial cells have the therapeutic potential to cure microvascular lesion.
To evaluate the efficacy and immune-regulatory impact of intra-arterial infusion of autologous CD133+ cells, we recruited 53 patients with diabetic PAD (27 of CD133+ group and 26 of control group).
CD133+ cells enriched from patients’ PB-MNCs were reinfused intra-arterially.
The ulcer healing followed up till 18 months was 100% (3/3) in CD133+ group and 60% (3/5) in control group.
The amputation rate was 0 (0/27) in CD133+ group and 11.54% (3/26) in control group.
Compared with the control group, TcPO2 and ABI showed obvious improvement at 18 months and significant increasing VEGF and decreasing IL-6 level in the CD133+ group within 4 weeks.
A reducing trend of proangiogenesis and anti-inflammatory regulation function at 4 weeks after the cells infusion was also found.
These results indicated that autologous CD133+ cell treatment can effectively improve the perfusion of morbid limb and exert proangiogenesis and anti-inflammatory immune-regulatory impacts by paracrine on tissue microenvironment.
The CD133+ progenitor cell therapy may be repeated at a fixed interval according to cell life span and immune-regulatory function.
American Psychological Association (APA)
Guang-Xing, Chen& Lian, Weishuai& Lou, Wensheng& Han, Shilong& Lu, Chenhui& Zhao, Chen…[et al.]. 2016. Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116999
Modern Language Association (MLA)
Guang-Xing, Chen…[et al.]. Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116999
American Medical Association (AMA)
Guang-Xing, Chen& Lian, Weishuai& Lou, Wensheng& Han, Shilong& Lu, Chenhui& Zhao, Chen…[et al.]. Transcatheter Arterial Infusion of Autologous CD133+ Cells for Diabetic Peripheral Artery Disease. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1116999