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Magnet-Bead Based MicroRNA Delivery System to Modify CD133+ Stem Cells
Joint Authors
Steinhoff, Gustav
Müller, Paula
Voronina, Natalia
Hausburg, Frauke
Lux, Cornelia A.
Wiekhorst, Frank
David, Robert
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-04
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Aim.
CD133+ stem cells bear huge potential for regenerative medicine.
However, low retention in the injured tissue and massive cell death reduce beneficial effects.
In order to address these issues, we intended to develop a nonviral system for appropriate cell engineering.
Materials and Methods.
Modification of human CD133+ stem cells with magnetic polyplexes carrying microRNA was studied in terms of efficiency, safety, and targeting potential.
Results.
High microRNA uptake rates (~80–90%) were achieved without affecting CD133+ stem cell properties.
Modified cells can be magnetically guided.
Conclusion.
We developed a safe and efficient protocol for CD133+ stem cell modification.
Our work may become a basis to improve stem cell therapeutical effects as well as their monitoring with magnetic resonance imaging.
American Psychological Association (APA)
Müller, Paula& Voronina, Natalia& Hausburg, Frauke& Lux, Cornelia A.& Wiekhorst, Frank& Steinhoff, Gustav…[et al.]. 2016. Magnet-Bead Based MicroRNA Delivery System to Modify CD133+ Stem Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117049
Modern Language Association (MLA)
Müller, Paula…[et al.]. Magnet-Bead Based MicroRNA Delivery System to Modify CD133+ Stem Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1117049
American Medical Association (AMA)
Müller, Paula& Voronina, Natalia& Hausburg, Frauke& Lux, Cornelia A.& Wiekhorst, Frank& Steinhoff, Gustav…[et al.]. Magnet-Bead Based MicroRNA Delivery System to Modify CD133+ Stem Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117049