Gingival Mesenchymal StemProgenitor Cells: A Unique Tissue Engineering Gem
Joint Authors
Fawzy El-Sayed, Karim M.
Dörfer, Christof E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-29
Country of Publication
Egypt
No. of Pages
16
Abstract EN
The human gingiva, characterized by its outstanding scarless wound healing properties, is a unique tissue and a pivotal component of the periodontal apparatus, investing and surrounding the teeth in their sockets in the alveolar bone.
In the last years gingival mesenchymal stem/progenitor cells (G-MSCs), with promising regenerative and immunomodulatory properties, have been isolated and characterized from the gingival lamina propria.
These cells, in contrast to other mesenchymal stem/progenitor cell sources, are abundant, readily accessible, and easily obtainable via minimally invasive cell isolation techniques.
The present review summarizes the current scientific evidence on G-MSCs’ isolation, their characterization, the investigated subpopulations, the generated induced pluripotent stem cells- (iPSC-) like G-MSCs, their regenerative properties, and current approaches for G-MSCs’ delivery.
The review further demonstrates their immunomodulatory properties, the transplantation preconditioning attempts via multiple biomolecules to enhance their attributes, and the experimental therapeutic applications conducted to treat multiple diseases in experimental animal models in vivo.
G-MSCs show remarkable tissue reparative/regenerative potential, noteworthy immunomodulatory properties, and primary experimental therapeutic applications of G-MSCs are very promising, pointing at future biologically based therapeutic techniques, being potentially superior to conventional clinical treatment modalities.
American Psychological Association (APA)
Fawzy El-Sayed, Karim M.& Dörfer, Christof E.. 2016. Gingival Mesenchymal StemProgenitor Cells: A Unique Tissue Engineering Gem. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117053
Modern Language Association (MLA)
Fawzy El-Sayed, Karim M.& Dörfer, Christof E.. Gingival Mesenchymal StemProgenitor Cells: A Unique Tissue Engineering Gem. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1117053
American Medical Association (AMA)
Fawzy El-Sayed, Karim M.& Dörfer, Christof E.. Gingival Mesenchymal StemProgenitor Cells: A Unique Tissue Engineering Gem. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117053
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117053