Micro- and Macrostructured PLGAGelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro
Joint Authors
Turinetto, Valentina
Giachino, Claudia
Cristallini, Caterina
Cibrario Rocchietti, Elisa
Gagliardi, Mariacristina
Mortati, Leonardo
Saviozzi, Silvia
Bellotti, Elena
Sassi, Maria Paola
Barbani, Niccoletta
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
16
Abstract EN
The biomaterial scaffold plays a key role in most tissue engineering strategies.
Its surface properties, micropatterning, degradation, and mechanical features affect not only the generation of the tissue construct in vitro, but also its in vivo functionality.
The area of myocardial tissue engineering still faces significant difficulties and challenges in the design of bioactive scaffolds, which allow composition variation to accommodate divergence in the evolving myocardial structure.
Here we aimed at verifying if a microstructured bioartificial scaffold alone can provoke an effect on stem cell behavior.
To this purpose, we fabricated microstructured bioartificial polymeric constructs made of PLGA/gelatin mimicking anisotropic structure and mechanical properties of the myocardium.
We found that PLGA/gelatin scaffolds promoted adhesion, elongation, ordered disposition, and early myocardial commitment of human mesenchymal stem cells suggesting that these constructs are able to crosstalk with stem cells in a precise and controlled manner.
At the same time, the biomaterial degradation kinetics renders the PLGA/gelatin constructs very attractive for myocardial regeneration approaches.
American Psychological Association (APA)
Cristallini, Caterina& Cibrario Rocchietti, Elisa& Gagliardi, Mariacristina& Mortati, Leonardo& Saviozzi, Silvia& Bellotti, Elena…[et al.]. 2016. Micro- and Macrostructured PLGAGelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117068
Modern Language Association (MLA)
Cristallini, Caterina…[et al.]. Micro- and Macrostructured PLGAGelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1117068
American Medical Association (AMA)
Cristallini, Caterina& Cibrario Rocchietti, Elisa& Gagliardi, Mariacristina& Mortati, Leonardo& Saviozzi, Silvia& Bellotti, Elena…[et al.]. Micro- and Macrostructured PLGAGelatin Scaffolds Promote Early Cardiogenic Commitment of Human Mesenchymal Stem Cells In Vitro. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117068
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117068