The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging
Joint Authors
Xu, Yan
Guo, Shilei
Wei, Cui
Li, Honglan
Chen, Lei
Yin, Chang
Zhang, Chuansen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-08
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Background.
Mesenchymal stem cells are the most commonly used seed cells in biomedical research and tissue engineering.
Their secretory proteins have also been proven to play an important role in tissue healing.
Methods.
We isolated adipose stem cells and placental stem cells and performed analysis examining characteristics.
The secretory proteins were extracted from conditioned medium and analyzed by MALDI-TOF/TOF.
The antiaging effect of conditioned mediums was evaluated by the results of facial skin application.
Results.
Adipose stem cells and placental stem cells were found to be very similar in their surface markers and multipotency.
The specific proteins secreted from adipose stem cells were more adept at cell adhesion, migration, wound healing, and tissue remodeling, while the proteins secreted by placental stem cells were more adept at angiogenesis, cell proliferation, differentiation, cell survival, immunomodulation, and collagen degradation.
While these two types of conditioned medium could improve the facial index, the improvement of Melanin index after injection of the adipose stem cell conditioned medium was much more significant.
Conclusion.
The results suggest that the secreted proteins are ideal cell-free substances for regeneration medicine, especially in the antiaging field.
American Psychological Association (APA)
Xu, Yan& Guo, Shilei& Wei, Cui& Li, Honglan& Chen, Lei& Yin, Chang…[et al.]. 2016. The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging. Stem Cells International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1117094
Modern Language Association (MLA)
Xu, Yan…[et al.]. The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1117094
American Medical Association (AMA)
Xu, Yan& Guo, Shilei& Wei, Cui& Li, Honglan& Chen, Lei& Yin, Chang…[et al.]. The Comparison of Adipose Stem Cell and Placental Stem Cell in Secretion Characteristics and in Facial Antiaging. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1117094
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117094