The Engrailed-1 Gene Stimulates Brown Adipogenesis
Joint Authors
Zhang, Chuanhai
Weng, Yibing
Shi, Fangxiong
Jin, Wanzhu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-11
Country of Publication
Egypt
No. of Pages
9
Abstract EN
As a thermogenic organ, brown adipose tissue (BAT) has received a great attention in treating obesity and related diseases.
It has been reported that brown adipocyte was derived from engrailed-1 (EN1) positive central dermomyotome.
However, functions of EN1 in brown adipogenesis are largely unknown.
Here we demonstrated that EN1 overexpression increased while EN1 knockdown decreased lipid accumulation and the expressions of key adipogenic genes including PPARγ2 and C/EBPα and mitochondrial OXPHOS as well as BAT specific marker UCP1.
Taken together, our findings clearly indicate that EN1 is a positive regulator of brown adipogenesis.
American Psychological Association (APA)
Zhang, Chuanhai& Weng, Yibing& Shi, Fangxiong& Jin, Wanzhu. 2016. The Engrailed-1 Gene Stimulates Brown Adipogenesis. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117100
Modern Language Association (MLA)
Zhang, Chuanhai…[et al.]. The Engrailed-1 Gene Stimulates Brown Adipogenesis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1117100
American Medical Association (AMA)
Zhang, Chuanhai& Weng, Yibing& Shi, Fangxiong& Jin, Wanzhu. The Engrailed-1 Gene Stimulates Brown Adipogenesis. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117100