Implant Composed of Demineralized Bone and Mesenchymal Stem Cells Genetically Modified with AdBMP2AdBMP7 for the Regeneration of Bone Fractures in Ovis aries
Joint Authors
Rojas-Martinez, Augusto
Ortiz-Lopez, Rocio
Hernandez-Hurtado, Adelina A.
Borrego-Soto, Gissela
Marino-Martinez, Ivan A.
Lara-Arias, Jorge
Romero-Diaz, Viktor J.
Abrego-Guerra, Adalberto
Vilchez-Cavazos, Jose F.
Elizondo-Riojas, Guillermo
Espinoza-Juarez, Marcela A.
Lopez-Romero, Gloria C.
Robles-Zamora, Alejandro
Mendoza Lemus, Oscar F.
Martínez-Rodríguez, Herminia Guadalupe
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-13
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Adipose-derived mesenchymal stem cells (ADMSCs) are inducible to an osteogenic phenotype by the bone morphogenetic proteins (BMPs).
This facilitates the generation of implants for bone tissue regeneration.
This study evaluated the in vitro osteogenic differentiation of ADMSCs transduced individually and in combination with adenoviral vectors expressing BMP2 and BMP7.
Moreover, the effectiveness of the implant containing ADMSCs transduced with the adenoviral vectors AdBMP2/AdBMP7 and embedded in demineralized bone matrix (DBM) was tested in a model of tibial fracture in sheep.
This graft was compared to ewes implanted with untransduced ADMSCs embedded in the same matrix and with injured but untreated animals.
In vivo results showed accelerated osteogenesis in the group treated with the AdBMP2/AdBMP7 transduced ADMSC graft, which also showed improved restoration of the normal bone morphology.
American Psychological Association (APA)
Hernandez-Hurtado, Adelina A.& Borrego-Soto, Gissela& Marino-Martinez, Ivan A.& Lara-Arias, Jorge& Romero-Diaz, Viktor J.& Abrego-Guerra, Adalberto…[et al.]. 2016. Implant Composed of Demineralized Bone and Mesenchymal Stem Cells Genetically Modified with AdBMP2AdBMP7 for the Regeneration of Bone Fractures in Ovis aries. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117106
Modern Language Association (MLA)
Hernandez-Hurtado, Adelina A.…[et al.]. Implant Composed of Demineralized Bone and Mesenchymal Stem Cells Genetically Modified with AdBMP2AdBMP7 for the Regeneration of Bone Fractures in Ovis aries. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117106
American Medical Association (AMA)
Hernandez-Hurtado, Adelina A.& Borrego-Soto, Gissela& Marino-Martinez, Ivan A.& Lara-Arias, Jorge& Romero-Diaz, Viktor J.& Abrego-Guerra, Adalberto…[et al.]. Implant Composed of Demineralized Bone and Mesenchymal Stem Cells Genetically Modified with AdBMP2AdBMP7 for the Regeneration of Bone Fractures in Ovis aries. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117106
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117106