Cellular Reprogramming Using Defined Factors and MicroRNAs
Joint Authors
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-12
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Development of human bodies, organs, and tissues contains numerous steps of cellular differentiation including an initial zygote, embryonic stem (ES) cells, three germ layers, and multiple expertized lineages of cells.
Induced pluripotent stem (iPS) cells have been recently developed using defined reprogramming factors such as Nanog, Klf5, Oct3/4 (Pou5f1), Sox2, and Myc.
This outstanding innovation is largely changing life science and medicine.
Methods of direct reprogramming of cells into myocytes, neurons, chondrocytes, and osteoblasts have been further developed using modified combination of factors such as N-myc, L-myc, Sox9, and microRNAs in defined cell/tissue culture conditions.
Mesenchymal stem cells (MSCs) and dental pulp stem cells (DPSCs) are also emerging multipotent stem cells with particular microRNA expression signatures.
It was shown that miRNA-720 had a role in cellular reprogramming through targeting the pluripotency factor Nanog and induction of DNA methyltransferases (DNMTs).
This review reports histories, topics, and idea of cellular reprogramming.
American Psychological Association (APA)
Eguchi, Takanori& Kuboki, Takuo. 2016. Cellular Reprogramming Using Defined Factors and MicroRNAs. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117123
Modern Language Association (MLA)
Eguchi, Takanori& Kuboki, Takuo. Cellular Reprogramming Using Defined Factors and MicroRNAs. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117123
American Medical Association (AMA)
Eguchi, Takanori& Kuboki, Takuo. Cellular Reprogramming Using Defined Factors and MicroRNAs. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117123