Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns
Joint Authors
Zhang, Weiwei
Jiao, Bin
Zhou, Miaojin
Zhou, Tao
Shen, Lu
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-24
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Alzheimer’s disease (AD) is the most prevalent type of dementia and its pathology is characterized by deposition of extracellular β-amyloid plaques, intracellular neurofibrillary tangles, and extensive neuron loss.
While only a few familial AD cases are due to mutations in three causative genes (APP, PSEN1, and PSEN2), the ultimate cause behind the rest of the cases, called sporadic AD, remains unknown.
Current animal and cellular models of human AD, which are based on the Aβ and tau hypotheses only, partially resemble the familial AD.
As a result, there is a pressing need for the development of new models providing insights into the pathological mechanisms of AD and for the discovery of ways to treat or delay the onset of the disease.
Recent preclinical research suggests that stem cells can be used to model AD.
Indeed, human induced pluripotent stem cells can be differentiated into disease-relevant cell types that recapitulate the unique genome of a sporadic AD patient or family member.
In this review, we will first summarize the current research findings on the genetic and pathological mechanisms of AD.
We will then highlight the existing induced pluripotent stem cell models of AD and, lastly, discuss the potential clinical applications in this field.
American Psychological Association (APA)
Zhang, Weiwei& Jiao, Bin& Zhou, Miaojin& Zhou, Tao& Shen, Lu. 2016. Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117155
Modern Language Association (MLA)
Zhang, Weiwei…[et al.]. Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117155
American Medical Association (AMA)
Zhang, Weiwei& Jiao, Bin& Zhou, Miaojin& Zhou, Tao& Shen, Lu. Modeling Alzheimer’s Disease with Induced Pluripotent Stem Cells: Current Challenges and Future Concerns. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117155