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Glioma Stem Cells: Signaling, Microenvironment, and Therapy
Joint Authors
Liebelt, Brandon D.
Shingu, Takashi
Zhou, Xin
Ren, Jiangong
Shin, Seul A.
Hu, Jian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Glioblastoma remains the most common and devastating primary brain tumor despite maximal therapy with surgery, chemotherapy, and radiation.
The glioma stem cell (GSC) subpopulation has been identified in glioblastoma and likely plays a key role in resistance of these tumors to conventional therapies as well as recurrent disease.
GSCs are capable of self-renewal and differentiation; glioblastoma-derived GSCs are capable of de novo tumor formation when implanted in xenograft models.
Further, GSCs possess unique surface markers, modulate characteristic signaling pathways to promote tumorigenesis, and play key roles in glioma vascular formation.
These features, in addition to microenvironmental factors, present possible targets for specifically directing therapy against the GSC population within glioblastoma.
In this review, the authors summarize the current knowledge of GSC biology and function and the role of GSCs in new vascular formation within glioblastoma and discuss potential therapeutic approaches to target GSCs.
American Psychological Association (APA)
Liebelt, Brandon D.& Shingu, Takashi& Zhou, Xin& Ren, Jiangong& Shin, Seul A.& Hu, Jian. 2016. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117159
Modern Language Association (MLA)
Liebelt, Brandon D.…[et al.]. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117159
American Medical Association (AMA)
Liebelt, Brandon D.& Shingu, Takashi& Zhou, Xin& Ren, Jiangong& Shin, Seul A.& Hu, Jian. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117159
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117159