A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research
Joint Authors
Kálmán, Sára
Hathy, Edit
Réthelyi, János M.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
21
Abstract EN
Neuronal differentiation of induced pluripotent stem cells and direct reprogramming represent powerful methods for modeling the development of neurons in vitro.
Moreover, this approach is also a means for comparing various cellular phenotypes between cell lines originating from healthy and diseased individuals or isogenic cell lines engineered to differ at only one or a few genomic loci.
Despite methodological constraints and initial skepticism regarding this approach, the field is expanding at a fast pace.
The improvements include the development of new differentiation protocols resulting in selected neuronal populations (e.g., dopaminergic, GABAergic, hippocampal, and cortical), the widespread use of genome editing methods, and single-cell techniques.
A major challenge awaiting in vitro disease modeling is the integration of clinical data in the models, by selection of well characterized clinical populations.
Ideally, these models will also demonstrate how different diagnostic categories share overlapping molecular disease mechanisms, but also have unique characteristics.
In this review we evaluate studies with regard to the described developments, to demonstrate how differentiation of induced pluripotent stem cells and direct reprogramming can contribute to psychiatry.
American Psychological Association (APA)
Kálmán, Sára& Hathy, Edit& Réthelyi, János M.. 2015. A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research. Stem Cells International،Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1117162
Modern Language Association (MLA)
Kálmán, Sára…[et al.]. A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-21.
https://search.emarefa.net/detail/BIM-1117162
American Medical Association (AMA)
Kálmán, Sára& Hathy, Edit& Réthelyi, János M.. A Dishful of a Troubled Mind: Induced Pluripotent Stem Cells in Psychiatric Research. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-21.
https://search.emarefa.net/detail/BIM-1117162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117162