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Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies
Joint Authors
Vacca, Angelo
Melaccio, Assunta
Lamanuzzi, Aurelia
Saltarella, Ilaria
Dammacco, Franco
Ria, Roberto
Reale, Antonia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
11
Abstract EN
It was believed that vasculogenesis occurred only during embryo life and that postnatal formation of vessels arose from angiogenesis.
Recent findings demonstrate the existence of Endothelial Precursor Cells (EPCs), which take partin postnatal vasculogenesis.
EPCs are recruited from the bone marrow under the stimulation of growth factors and cytokines and reach the sites of neovascularization in both physiological and pathological conditions such as malignancies where they contribute to the “angiogenic switch” and tumor progression.
An implementation of circulating EPCs in the bloodstream of patients with haematological malignancies has been demonstrated.
This increase is strictly related to the bone marrow microvessel density and correlated with a poor prognosis.
The EPCs characterization is a very complex process and still under investigation.
This literature review aims to provide an overview of the functional and biological role of EPCs in haematological malignancies and to investigate their potential as a new cancer therapeutic target.
American Psychological Association (APA)
Reale, Antonia& Melaccio, Assunta& Lamanuzzi, Aurelia& Saltarella, Ilaria& Dammacco, Franco& Vacca, Angelo…[et al.]. 2015. Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1117178
Modern Language Association (MLA)
Reale, Antonia…[et al.]. Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1117178
American Medical Association (AMA)
Reale, Antonia& Melaccio, Assunta& Lamanuzzi, Aurelia& Saltarella, Ilaria& Dammacco, Franco& Vacca, Angelo…[et al.]. Functional and Biological Role of Endothelial Precursor Cells in Tumour Progression: A New Potential Therapeutic Target in Haematological Malignancies. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1117178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117178