Single File Flow of Biomimetic Beads for Continuous SERS Recording in a Microfluidic Device
Joint Authors
Calzavara, Diego
Ferraro, Davide
Litti, Lucio
Cappozzo, Greshia
Mistura, Giampaolo
Meneghetti, Moreno
Pierno, Matteo
Source
Advances in Condensed Matter Physics
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A major challenge in cancer treatment is the quantification of biomarkers associated with a specific cancer type.
Important biomarkers are the circulating tumor cells (CTCs) detached from the main cancer and circulating in the blood.
CTCs are very rare and their identification is still an issue.
Although CTCs quantification can be estimated by using fluorescent markers, all the fluorescence techniques are strongly limited by the number of emissions (therefore markers) that can be discriminated with one exciting line, by their bleaching characteristics, and by the intrinsic autofluorescence of biological samples.
An emerging technique that can overcome these limitations is Surface Enhanced Raman Scattering (SERS).
Signals of vibrational origin with intensity similar to those of fluorescence, but narrower bandwidths, can be easily discriminated even by exciting with a single laser line.
We recently showed the benefit of this method with cells fixed on a surface.
However, this approach is too demanding to be applied in clinical routine.
To effectively increase the throughput of the SERS analysis, microfluidics represents a promising tool.
We report two different hydrodynamic strategies, based on device geometry and liquids viscosity, to successfully combine a microfluidic design with SERS.
American Psychological Association (APA)
Calzavara, Diego& Ferraro, Davide& Litti, Lucio& Cappozzo, Greshia& Mistura, Giampaolo& Meneghetti, Moreno…[et al.]. 2018. Single File Flow of Biomimetic Beads for Continuous SERS Recording in a Microfluidic Device. Advances in Condensed Matter Physics،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117183
Modern Language Association (MLA)
Calzavara, Diego…[et al.]. Single File Flow of Biomimetic Beads for Continuous SERS Recording in a Microfluidic Device. Advances in Condensed Matter Physics No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1117183
American Medical Association (AMA)
Calzavara, Diego& Ferraro, Davide& Litti, Lucio& Cappozzo, Greshia& Mistura, Giampaolo& Meneghetti, Moreno…[et al.]. Single File Flow of Biomimetic Beads for Continuous SERS Recording in a Microfluidic Device. Advances in Condensed Matter Physics. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117183