Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease
Joint Authors
Imbalzano, Egidio
Aragona, Caterina Oriana
Mamone, Federica
Cairo, Valentina
Lo Gullo, Alberto
D’Ascola, Angela
Sardo, Maria Adriana
Scuruchi, Michele
Basile, Giorgio
Saitta, Antonino
Mandraffino, Giuseppe
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Objective.
To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies.
Data Sources.
MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”.
Study Selection.
Database hits were evaluated against explicit inclusion criteria.
From 927 database hits, 43 quantitative studies were included.
Data Syntheses.
EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers.
Conclusions.
EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings.
Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases.
This trial is registered with registration number: Prospero CRD42015023717.
American Psychological Association (APA)
Aragona, Caterina Oriana& Imbalzano, Egidio& Mamone, Federica& Cairo, Valentina& Lo Gullo, Alberto& D’Ascola, Angela…[et al.]. 2015. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117189
Modern Language Association (MLA)
Aragona, Caterina Oriana…[et al.]. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117189
American Medical Association (AMA)
Aragona, Caterina Oriana& Imbalzano, Egidio& Mamone, Federica& Cairo, Valentina& Lo Gullo, Alberto& D’Ascola, Angela…[et al.]. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117189
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117189