Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease

Joint Authors

Imbalzano, Egidio
Aragona, Caterina Oriana
Mamone, Federica
Cairo, Valentina
Lo Gullo, Alberto
D’Ascola, Angela
Sardo, Maria Adriana
Scuruchi, Michele
Basile, Giorgio
Saitta, Antonino
Mandraffino, Giuseppe

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-12-29

Country of Publication

Egypt

No. of Pages

12

Abstract EN

Objective.

To identify, evaluate, and synthesize evidence on the predictive power of circulating endothelial progenitor cells (EPCs) in cardiovascular disease, through a systematic review of quantitative studies.

Data Sources.

MEDLINE was searched using keywords related to “endothelial progenitor cells” and “endothelium” and, for the different categories, respectively, “smoking”; “blood pressure”; “diabetes mellitus” or “insulin resistance”; “dyslipidemia”; “aging” or “elderly”; “angina pectoris” or “myocardial infarction”; “stroke” or “cerebrovascular disease”; “homocysteine”; “C-reactive protein”; “vitamin D”.

Study Selection.

Database hits were evaluated against explicit inclusion criteria.

From 927 database hits, 43 quantitative studies were included.

Data Syntheses.

EPC count has been suggested for cardiovascular risk estimation in the clinical practice, since it is currently accepted that EPCs can work as proangiogenic support cells, maintaining their importance as regenerative/reparative potential, and also as prognostic markers.

Conclusions.

EPCs showed an important role in identifying cardiovascular risk conditions, and to suggest their evaluation as predictor of outcomes appears to be reasonable in different defined clinical settings.

Due to their capability of proliferation, circulation, and the development of functional progeny, great interest has been directed to therapeutic use of progenitor cells in atherosclerotic diseases.

This trial is registered with registration number: Prospero CRD42015023717.

American Psychological Association (APA)

Aragona, Caterina Oriana& Imbalzano, Egidio& Mamone, Federica& Cairo, Valentina& Lo Gullo, Alberto& D’Ascola, Angela…[et al.]. 2015. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117189

Modern Language Association (MLA)

Aragona, Caterina Oriana…[et al.]. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117189

American Medical Association (AMA)

Aragona, Caterina Oriana& Imbalzano, Egidio& Mamone, Federica& Cairo, Valentina& Lo Gullo, Alberto& D’Ascola, Angela…[et al.]. Endothelial Progenitor Cells for Diagnosis and Prognosis in Cardiovascular Disease. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117189

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1117189