Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation
Joint Authors
Bruno, Stefania
Grange, Cristina
Tapparo, Marta
Pasquino, Chiara
Romagnoli, Renato
Dametto, Ennia
Amoroso, Antonio
Tetta, Ciro
Camussi, Giovanni
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-04-04
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Human liver stem cells (HLSCs) are a mesenchymal stromal cell-like population resident in the adult liver.
Preclinical studies indicate that HLSCs could be a good candidate for cell therapy.
The aim of the present study was to evaluate the immunogenicity and the immunomodulatory properties of HLSCs on T-lymphocytes, natural killer cells (NKs), and dendritic cells (DCs) in allogeneic experimental settings.
We found that HLSCs inhibited T-cell proliferation by a mechanism independent of cell contact and dependent on the release of prostaglandin E2 (PGE2) and on indoleamine 2,3-dioxygenase activity.
When compared with mesenchymal stromal cells (MSCs), HLSCs were more efficient in inhibiting T-cell proliferation.
At variance with MSCs, HLSCs did not elicit NK degranulation.
Moreover, HLSCs inhibited NK degranulation against K562, a NK-sensitive target, by a mechanism dependent on HLA-G release.
When tested on DC generation from monocytes, HLSCs were found to impair DC differentiation and DCs ability to induce T-cell proliferation through PGE2.
This study shows that HLSCs have immunomodulatory properties similar to MSCs, but, at variance with MSCs, they do not elicit a NK response.
American Psychological Association (APA)
Bruno, Stefania& Grange, Cristina& Tapparo, Marta& Pasquino, Chiara& Romagnoli, Renato& Dametto, Ennia…[et al.]. 2016. Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation. Stem Cells International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1117270
Modern Language Association (MLA)
Bruno, Stefania…[et al.]. Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1117270
American Medical Association (AMA)
Bruno, Stefania& Grange, Cristina& Tapparo, Marta& Pasquino, Chiara& Romagnoli, Renato& Dametto, Ennia…[et al.]. Human Liver Stem Cells Suppress T-Cell Proliferation, NK Activity, and Dendritic Cell Differentiation. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1117270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117270