Probing Neural Transplant Networks In Vivo with Optogenetics and Optogenetic fMRI
Joint Authors
Weitz, Andrew J.
Lee, Jin Hyung
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-12
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Understanding how stem cell-derived neurons functionally integrate into the brain upon transplantation has been a long sought-after goal of regenerative medicine.
However, methodological limitations have stood as a barrier, preventing key insight into this fundamental problem.
A recently developed technology, termed optogenetic functional magnetic resonance imaging (ofMRI), offers a possible solution.
By combining targeted activation of transplanted neurons with large-scale, noninvasive measurements of brain activity, ofMRI can directly visualize the effect of engrafted neurons firing on downstream regions.
Importantly, this tool can be used to identify not only whether transplanted neurons have functionally integrated into the brain, but also which regions they influence and how.
Furthermore, the precise control afforded over activation enables the input-output properties of engrafted neurons to be systematically studied.
This review summarizes the efforts in stem cell biology and neuroimaging that made this development possible and outlines its potential applications for improving and optimizing stem cell-based therapies in the future.
American Psychological Association (APA)
Weitz, Andrew J.& Lee, Jin Hyung. 2016. Probing Neural Transplant Networks In Vivo with Optogenetics and Optogenetic fMRI. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117295
Modern Language Association (MLA)
Weitz, Andrew J.& Lee, Jin Hyung. Probing Neural Transplant Networks In Vivo with Optogenetics and Optogenetic fMRI. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1117295
American Medical Association (AMA)
Weitz, Andrew J.& Lee, Jin Hyung. Probing Neural Transplant Networks In Vivo with Optogenetics and Optogenetic fMRI. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117295