Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HACollagenPLA Scaffold
Joint Authors
E, Lingling
Liu, Hongchen
Wang, Xing
Xing, Helin
Zhang, Guilan
Wu, Xia
Zou, Xuan
Feng, Lin
Wang, Dongsheng
Li, Meng
Zhao, Jing
Du, Jianwei
Lv, Yan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-28
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Periodontal bone defects occur in a wide variety of clinical situations.
Adult stem cell- and biomaterial-based bone tissue regeneration are a promising alternative to natural bone grafts.
Recent evidence has demonstrated that two populations of adult bone marrow mesenchymal stromal cells (BMSCs) can be distinguished based on their embryonic origins.
These BMSCs are not interchangeable, as bones preferentially heal using cells that share the same embryonic origin.
However, the feasibility of tissue engineering using human craniofacial BMSCs was unclear.
The goal of this study was to explore human craniofacial BMSC-based therapy for the treatment of localized mandibular defects using a standardized, minimally invasive procedure.
The BMSCs’ identity was confirmed.
Scanning electron microscopy, a cell proliferation assay, and supernatant detection indicated that the nHAC/PLA provided a suitable environment for aBMSCs.
Real-time PCR and electrochemiluminescence immunoassays demonstrated that osteogenic markers were upregulated by osteogenic preinduction.
Moreover, in a rabbit critical-size mandibular bone defect model, total bone formation in the nHAC/PLA + aBMSCs group was significantly higher than in the nHAC/PLA group but significantly lower than in the nHAC/PLA + preinduced aBMSCs.
These findings demonstrate that this engineered bone is a valid alternative for the correction of mandibular bone defects.
American Psychological Association (APA)
Wang, Xing& Xing, Helin& Zhang, Guilan& Wu, Xia& Zou, Xuan& Feng, Lin…[et al.]. 2016. Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HACollagenPLA Scaffold. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1117322
Modern Language Association (MLA)
Wang, Xing…[et al.]. Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HACollagenPLA Scaffold. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1117322
American Medical Association (AMA)
Wang, Xing& Xing, Helin& Zhang, Guilan& Wu, Xia& Zou, Xuan& Feng, Lin…[et al.]. Restoration of a Critical Mandibular Bone Defect Using Human Alveolar Bone-Derived Stem Cells and Porous Nano-HACollagenPLA Scaffold. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1117322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117322