Electrically Induced Calcium Handling in Cardiac Progenitor Cells
Joint Authors
Maxwell, Joshua T.
Davis, Michael E.
Wagner, Mary B.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-12
Country of Publication
Egypt
No. of Pages
11
Abstract EN
For nearly a century, the heart was viewed as a terminally differentiated organ until the discovery of a resident population of cardiac stem cells known as cardiac progenitor cells (CPCs).
It has been shown that the regenerative capacity of CPCs can be enhanced by ex vivo modification.
Preconditioning CPCs could provide drastic improvements in cardiac structure and function; however, a systematic approach to determining a mechanistic basis for these modifications founded on the physiology of CPCs is lacking.
We have identified a novel property of CPCs to respond to electrical stimulation by initiating intracellular Ca2+ oscillations.
We used confocal microscopy and intracellular calcium imaging to determine the spatiotemporal properties of the Ca2+ signal and the key proteins involved in this process using pharmacological inhibition and confocal Ca2+ imaging.
Our results provide valuable insights into mechanisms to enhance the therapeutic potential in stem cells and further our understanding of human CPC physiology.
American Psychological Association (APA)
Maxwell, Joshua T.& Wagner, Mary B.& Davis, Michael E.. 2016. Electrically Induced Calcium Handling in Cardiac Progenitor Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1117345
Modern Language Association (MLA)
Maxwell, Joshua T.…[et al.]. Electrically Induced Calcium Handling in Cardiac Progenitor Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1117345
American Medical Association (AMA)
Maxwell, Joshua T.& Wagner, Mary B.& Davis, Michael E.. Electrically Induced Calcium Handling in Cardiac Progenitor Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1117345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117345