Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar
Joint Authors
Angelou, Valerie
Kalodimou, Vassiliki
Messini, Irini
Psychalakis, Nikolaos
Karampela, Eleftheria
Papalois, Apostolos E.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-06
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Background.
The aim of the study was to assess the histological effects of autologous infusion of adipose-derived stem cells (ADSC) on a chronic vocal fold scar in a rabbit model as compared to an untreated scar as well as in injection of hyaluronic acid.
Study Design.
Animal experiment.
Method.
We used 74 New Zealand rabbits.
Sixteen of them were used as control/normal group.
We created a bilateral vocal fold wound in the remaining 58 rabbits.
After 18 months we separated our population into three groups.
The first group served as control/scarred group.
The second one was injected with hyaluronic acid in the vocal folds, and the third received an autologous adipose-derived stem cell infusion in the scarred vocal folds (ADSC group).
We measured the variation of thickness of the lamina propria of the vocal folds and analyzed histopathologic changes in each group after three months.
Results.
The thickness of the lamina propria was significantly reduced in the group that received the ADSC injection, as compared to the normal/scarred group.
The collagen deposition, the hyaluronic acid, the elastin levels, and the organization of elastic fibers tend to return to normal after the injection of ADSC.
Conclusions.
Autologous injection of adipose-derived stem cells on a vocal fold chronic scar enhanced the healing of the vocal folds and the reduction of the scar tissue, even when compared to other treatments.
American Psychological Association (APA)
Angelou, Valerie& Kalodimou, Vassiliki& Messini, Irini& Psychalakis, Nikolaos& Karampela, Eleftheria& Papalois, Apostolos E.. 2016. Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117347
Modern Language Association (MLA)
Angelou, Valerie…[et al.]. Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117347
American Medical Association (AMA)
Angelou, Valerie& Kalodimou, Vassiliki& Messini, Irini& Psychalakis, Nikolaos& Karampela, Eleftheria& Papalois, Apostolos E.. Adipose-Derived Mesenchymal Stem Cells in the Regeneration of Vocal Folds: A Study on a Chronic Vocal Fold Scar. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117347
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117347