Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants
Joint Authors
Nothelfer, Katharina
Obermayr, Florian
Belz, Nadine
Reinartz, Ellen
Bareiss, Petra M.
Bühring, Hans-Jörg
Beschorner, Rudi
Just, Lothar
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
12
Abstract EN
The Wnt signalling pathway plays a crucial role in the development of the nervous system.
This signalling cascade is initiated upon binding of the secreted Wnt ligand to a member of the family of frizzled receptors.
In the present study, we analysed the presence of frizzled-4 in the enteric nervous system of human infants.
Frizzled-4 could be identified by immunohistochemistry in a subpopulation of enteric neuronal and glial cells in the small and large intestine.
Detection of frizzled-4 in the tunica muscularis by RT-PCR confirmed this receptor’s expression on the mRNA level.
Interestingly, we observed distinct cell populations that co-expressed frizzled-4 with the intermediate filament protein nestin and the neurotrophin receptor p75NTR, which have been reported to be expressed in neural progenitor cells.
Flow cytometry analysis revealed that 60% of p75NTR positive cells of the tunica muscularis were positive for frizzled-4.
Additionally, in pathological samples of Hirschsprung’s disease, the expression of this Wnt receptor correlated with the number of myenteric ganglion cells and decreased from normoganglionic to aganglionic areas of large intestine.
The expression pattern of frizzled-4 indicates that this Wnt receptor could be involved in postnatal development and/or function of the enteric nervous system.
American Psychological Association (APA)
Nothelfer, Katharina& Obermayr, Florian& Belz, Nadine& Reinartz, Ellen& Bareiss, Petra M.& Bühring, Hans-Jörg…[et al.]. 2015. Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117365
Modern Language Association (MLA)
Nothelfer, Katharina…[et al.]. Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1117365
American Medical Association (AMA)
Nothelfer, Katharina& Obermayr, Florian& Belz, Nadine& Reinartz, Ellen& Bareiss, Petra M.& Bühring, Hans-Jörg…[et al.]. Expression of the Wnt Receptor Frizzled-4 in the Human Enteric Nervous System of Infants. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1117365
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117365