Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues
Joint Authors
Mori, Giorgio
Di Benedetto, Adriana
Porro, Chiara
Trotta, Teresa
Posa, Francesca
Cavalcanti-Adam, Elisabetta A.
Brunetti, Giacomina
Grano, Maria
Colaianni, Graziana
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-13
Country of Publication
Egypt
No. of Pages
9
Abstract EN
1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D (Vit D), increases intestinal absorption of calcium and phosphate, maintaining a correct balance of bone remodeling.
Vit D has an anabolic effect on the skeletal system and is key in promoting osteoblastic differentiation of human Mesenchymal Stem Cells (hMSCs) from bone marrow.
MSCs can be also isolated from the immature form of the tooth, the dental bud: Dental Bud Stem Cells (DBSCs) are adult stem cells that can effectively undergo osteoblastic differentiation.
In this work we investigated the effect of Vit D on DBSCs differentiation into osteoblasts.
Our data demonstrate that DBSCs, cultured in an opportune osteogenic medium, differentiate into osteoblast-like cells; Vit D treatment stimulates their osteoblastic features, increasing the expression of typical markers of osteoblastogenesis like RUNX2 and Collagen I (Coll I) and, in a more important way, determining a higher production of mineralized matrix nodules.
American Psychological Association (APA)
Posa, Francesca& Di Benedetto, Adriana& Colaianni, Graziana& Cavalcanti-Adam, Elisabetta A.& Brunetti, Giacomina& Porro, Chiara…[et al.]. 2016. Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117373
Modern Language Association (MLA)
Posa, Francesca…[et al.]. Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1117373
American Medical Association (AMA)
Posa, Francesca& Di Benedetto, Adriana& Colaianni, Graziana& Cavalcanti-Adam, Elisabetta A.& Brunetti, Giacomina& Porro, Chiara…[et al.]. Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117373