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The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine
Joint Authors
Nishimura, Agnes L.
Hedges, Erin C.
Mehler, Vera J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-07
Country of Publication
Egypt
No. of Pages
9
Abstract EN
In recent years several genes have linked amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) as a spectrum disease; however little is known about what triggers their onset.
With the ability to generate patient specific stem cell lines from somatic cells, it is possible to model disease without the need to transfect cells with exogenous DNA.
These pluripotent stem cells have opened new avenues for identification of disease phenotypes and their relation to specific molecular pathways.
Thus, as never before, compounds with potential applications for regenerative medicine can be specifically tailored in patient derived cultures.
In this review, we discuss how patient specific induced pluripotent stem cells (iPSCs) have been used to model ALS and FTD and the most recent drug screening targets for these diseases.
We also discuss how an iPSC bank would improve the quality of the available cell lines and how it would increase knowledge about the ALS/FTD disease spectrum.
American Psychological Association (APA)
Hedges, Erin C.& Mehler, Vera J.& Nishimura, Agnes L.. 2016. The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117395
Modern Language Association (MLA)
Hedges, Erin C.…[et al.]. The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1117395
American Medical Association (AMA)
Hedges, Erin C.& Mehler, Vera J.& Nishimura, Agnes L.. The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117395
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117395