Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors
Joint Authors
Swarup, Neeti
Chowdhary, Zoya
Mehendiratta, Monica
Khatana, Shikha
Choi, Su Jung
Sagolsem, Chandarani
Nayak, Meghanand T.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Growth factors like bone morphogenetic protein 4 (BMP4) and fibroblast growth factor 8 (FGF8) play a major role in organogenesis and specifically in odontogenesis.
They are also believed to have a role in oncogenesis.
Thus, any discrepancies in their standard behavior and activity would lead to serious abnormalities including odontogenic cyst and tumors.
The present research work investigated the expression of BMP4 and FGF8 in odontogenic tumors (OT) and cyst as well as developing tooth germs to elucidate their roles.
Dental organs of various odontogenic stages and 30 OTs including solid multicystic ameloblastomas (SMA, 10 cases), ameloblastic fibroma (AF, 10 cases), odontogenic myxoma (OM, 10 cases), and odontogenic cysts: odontogenic keratocyst (OKC, 10 cases) were evaluated in both epithelial and mesenchymal components for the expression of BMP4 and FGF8 using immunohistochemistry.
The epithelial nuclear expression of BMP4 was highest in OKC (9 cases) while FGF8 was highest in SMA (10 cases).
The mesenchymal nuclear expression of both BMP4 (8 cases) (p=0.001) and FGF8 (9 cases) (p=0.045) were significantly high in OMs among all OTs.
Both growth factors were actively expressed in different stages of tooth development.
The expression of BMP4 and FGF8 corelates well with the proliferative component of the pathologies, indicating a possible role in the pathogenesis and progression.
American Psychological Association (APA)
Swarup, Neeti& Nayak, Meghanand T.& Chowdhary, Zoya& Mehendiratta, Monica& Khatana, Shikha& Choi, Su Jung…[et al.]. 2018. Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117408
Modern Language Association (MLA)
Swarup, Neeti…[et al.]. Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors. Analytical Cellular Pathology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1117408
American Medical Association (AMA)
Swarup, Neeti& Nayak, Meghanand T.& Chowdhary, Zoya& Mehendiratta, Monica& Khatana, Shikha& Choi, Su Jung…[et al.]. Evaluation and Immunolocalization of BMP4 and FGF8 in Odontogenic Cyst and Tumors. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117408