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Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2ARE Pathways
Joint Authors
Chen, Meihui
Hou, Yu
Lin, Dingkun
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-06
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Polydatin, a glucoside of resveratrol, has been reported to possess potent antioxidative effects.
In the present study, we aimed to investigate the effects of polydatin in bone marrow-derived mesenchymal stem cells (BMSCs) death caused by hydrogen peroxide (H2O2), imitating the microenvironment surrounding transplanted cells in the injured spinal cord in vitro.
In our study, MTT results showed that polydatin effectively prevented the decrease of cell viability caused by H2O2.
Hochest 33258, Annexin V-PI, and Western blot assay showed H2O2-induced apoptosis in BMSCs, which was attenuated by polydatin.
Further studies indicated that polydatin significantly protects BMSCs against apoptosis due to its antioxidative effects and the regulation of Nrf 2/ARE pathway.
Taken together, our results indicate that polydatin could be used in combination with BMSCs for the treatment of spinal cord injury by improving the cell survival and oxidative stress microenvironments.
American Psychological Association (APA)
Chen, Meihui& Hou, Yu& Lin, Dingkun. 2015. Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2ARE Pathways. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117413
Modern Language Association (MLA)
Chen, Meihui…[et al.]. Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2ARE Pathways. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117413
American Medical Association (AMA)
Chen, Meihui& Hou, Yu& Lin, Dingkun. Polydatin Protects Bone Marrow Stem Cells against Oxidative Injury: Involvement of Nrf 2ARE Pathways. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117413