Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary
Joint Authors
Urzua, Ulises
Chacon, Carlos
Espinoza, Renato
Martínez, Sebastián
Hernandez, Nicole
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The progressive decline of the ovarian follicle pool leads to reproductive ageing.
The latter is accompanied by age-related disorders, including various types of cancer.
In fact, the highest rates of ovarian cancer (OC) occur at postmenopause while OC risk is significantly modulated by parity records during previous fertile life.
We approached the age-parity relationship in the C57BL/6 mouse model and herein describe the presence of nonheme iron (hemosiderin) and deposits of the “age pigment” lipofuscin in reproductively aged mouse ovaries by applying conventional histochemical methods and autofluorescence.
In addition, the 8-OHdG adduct was evaluated in ovarian genomic DNA.
Both hemosiderin and lipofuscin were significantly higher in virgin compared to multiparous ovaries.
The same pattern was observed for 8-OHdG.
We conclude that nulliparity induces a long-term accumulation of iron and lipofuscin with concomitant oxidative damage to DNA in the mouse ovary.
Since lipofuscin is a widely accepted senescence marker and given the recently postulated role of lipofuscin-associated iron as a source of reactive oxygen species (ROS) in senescent cells, these findings suggest a possible pathogenic mechanism by which nulliparity contributes to an increased OC risk in the postmenopausal ovary.
American Psychological Association (APA)
Urzua, Ulises& Chacon, Carlos& Espinoza, Renato& Martínez, Sebastián& Hernandez, Nicole. 2018. Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117419
Modern Language Association (MLA)
Urzua, Ulises…[et al.]. Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary. Analytical Cellular Pathology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1117419
American Medical Association (AMA)
Urzua, Ulises& Chacon, Carlos& Espinoza, Renato& Martínez, Sebastián& Hernandez, Nicole. Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1117419
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117419