Comparison of Immunomodulation Properties of Porcine Mesenchymal StromalStem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue

Joint Authors

Jeon, Ryoung-Hoon
Baregundi Subbarao, Raghavendra
Lee, Sung-Lim
Rho, Gyu-Jin
Ock, Sun-A
Lee, Yeon-Mi
Lee, Jeong-Hyeon
Park, Ji Kwon
Hwang, Sun-Chul

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-12-21

Country of Publication

Egypt

No. of Pages

15

Abstract EN

Mesenchymal stromal/stem cells (MSCs) demonstrate immunomodulation capacity that has been implicated in the reduction of graft-versus-host disease.

Accordingly, we herein investigated the capacity of MSCs derived from several tissue sources to modulate both proinflammatory (interferon [IFN] γ and tumor necrosis factor [TNF] α) and immunosuppressive cytokines (transforming growth factor [TGF] β and interleukin [IL] 10) employing xenogeneic human MSC-mixed lymphocyte reaction (MLR) test.

Bone marrow-derived MSCs showed higher self-renewal capacity with relatively slow proliferation rate in contrast to adipose-derived MSCs which displayed higher proliferation rate.

Except for the lipoprotein gene, there were no marked changes in osteogenesis- and adipogenesis-related genes following in vitro differentiation; however, the histological marker analysis revealed that adipose MSCs could be differentiated into both adipose and bone tissue.

TGFβ and IL10 were detected in adipose MSCs and bone marrow MSCs, respectively.

However, skin-derived MSCs expressed both IFNγ and IL10, which may render them sensitive to immunomodulation.

The xenogeneic human MLR test revealed that MSCs had a partial immunomodulation capacity, as proliferation of activated and resting peripheral blood mononuclear cells was not affected, but this did not differ among MSC sources.

MSCs were not tumorigenic when introduced into immunodeficient mice.

We concluded that the characteristics of MSCs are tissue source-dependent and their in vivo application requires more in-depth investigation regarding their precise immunomodulation capacities.

American Psychological Association (APA)

Ock, Sun-A& Baregundi Subbarao, Raghavendra& Lee, Yeon-Mi& Lee, Jeong-Hyeon& Jeon, Ryoung-Hoon& Lee, Sung-Lim…[et al.]. 2015. Comparison of Immunomodulation Properties of Porcine Mesenchymal StromalStem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1117434

Modern Language Association (MLA)

Ock, Sun-A…[et al.]. Comparison of Immunomodulation Properties of Porcine Mesenchymal StromalStem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1117434

American Medical Association (AMA)

Ock, Sun-A& Baregundi Subbarao, Raghavendra& Lee, Yeon-Mi& Lee, Jeong-Hyeon& Jeon, Ryoung-Hoon& Lee, Sung-Lim…[et al.]. Comparison of Immunomodulation Properties of Porcine Mesenchymal StromalStem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1117434

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1117434