High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis
Joint Authors
Tsinias, Georgios
Bravou, Vasiliki
Nikou, Sofia
Papadas, Theodoros
Pitsos, Panagiotis
Papadaki, Helen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Focal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis.
Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton.
Altered expression of these proteins has been implicated in human cancer.
This study addresses their expression and prognostic significance in human laryngeal carcinoma.
Protein expressions of cofilin, N-WASP, α-parvin, β-parvin, and PINCH1 were examined by immunohistochemistry in 72 human laryngeal squamous cell carcinomas.
Correlations with clinicopathological data and survival were evaluated.
All proteins examined were overexpressed in human laryngeal carcinomas compared to adjacent nonneoplastic epithelium.
High expression of PINCH1 was associated significantly with high grade, lymph node-positive, and advanced stage disease.
Moreover, high PINCH1 expression significantly associated with poor overall and disease-free survival and high cytoplasmic PINCH1 expression was shown by multivariate analysis to independently predict poor overall survival.
In conclusion, we provide novel evidence that focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease.
American Psychological Association (APA)
Tsinias, Georgios& Nikou, Sofia& Papadas, Theodoros& Pitsos, Panagiotis& Papadaki, Helen& Bravou, Vasiliki. 2018. High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1117440
Modern Language Association (MLA)
Tsinias, Georgios…[et al.]. High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis. Analytical Cellular Pathology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1117440
American Medical Association (AMA)
Tsinias, Georgios& Nikou, Sofia& Papadas, Theodoros& Pitsos, Panagiotis& Papadaki, Helen& Bravou, Vasiliki. High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1117440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117440