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Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells
Joint Authors
Tan, Botao
Luo, Zeruxin
Yue, Yan
Liu, Yuan
Pan, Li
Yu, Lehua
Yin, Ying
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-18
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Insufficient proliferation, differentiation, and migration are the main pitfalls of neural stem cells (NSCs) in reparative therapeutics for the central nervous system (CNS) diseases.
The potent lipid mediator sphingosine-1-phosphate (S1P) regulates cells’ biological behavior broadly in the CNS.
However, the effects of activating S1P on NSCs are not quite clear.
In the current study, FTY720 (Fingolimod), an analog of S1P, was employed to induce the proliferation, differentiation, and migration of cultured brain-derived NSCs.
The results indicated that proliferation and migration ability of NSCs were promoted by FTY720.
Though we observed no obvious neuron prefers differentiation of NSCs, there were more protoplasmic astrocytes developed in the presence of certain concentration of FTY720.
This work gives more comprehensive understanding of how FTY720 affects NSCs.
American Psychological Association (APA)
Tan, Botao& Luo, Zeruxin& Yue, Yan& Liu, Yuan& Pan, Li& Yu, Lehua…[et al.]. 2016. Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117446
Modern Language Association (MLA)
Tan, Botao…[et al.]. Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117446
American Medical Association (AMA)
Tan, Botao& Luo, Zeruxin& Yue, Yan& Liu, Yuan& Pan, Li& Yu, Lehua…[et al.]. Effects of FTY720 (Fingolimod) on Proliferation, Differentiation, and Migration of Brain-Derived Neural Stem Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117446