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Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells
Joint Authors
Just, Lothar
Neckel, Peter Helmut
Mohr, Roland
Zhang, Ying
Hirt, Bernhard
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-11-30
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Postnatal neural progenitor cells of the enteric nervous system are a potential source for future cell replacement therapies of developmental dysplasia like Hirschsprung’s disease.
However, little is known about the molecular mechanisms driving the homeostasis and differentiation of this cell pool.
In this work, we conducted Affymetrix GeneChip experiments to identify differences in gene regulation between proliferation and early differentiation of enteric neural progenitors from neonatal mice.
We detected a total of 1333 regulated genes that were linked to different groups of cellular mechanisms involved in cell cycle, apoptosis, neural proliferation, and differentiation.
As expected, we found an augmented inhibition in the gene expression of cell cycle progression as well as an enhanced mRNA expression of neuronal and glial differentiation markers.
We further found a marked inactivation of the canonical Wnt pathway after the induction of cellular differentiation.
Taken together, these data demonstrate the various molecular mechanisms taking place during the proliferation and early differentiation of enteric neural progenitor cells.
American Psychological Association (APA)
Neckel, Peter Helmut& Mohr, Roland& Zhang, Ying& Hirt, Bernhard& Just, Lothar. 2015. Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1117455
Modern Language Association (MLA)
Neckel, Peter Helmut…[et al.]. Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1117455
American Medical Association (AMA)
Neckel, Peter Helmut& Mohr, Roland& Zhang, Ying& Hirt, Bernhard& Just, Lothar. Comparative Microarray Analysis of Proliferating and Differentiating Murine ENS Progenitor Cells. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1117455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117455