Human Cellular Models for the Investigation of Lung Inflammation and Mucus Production in Cystic Fibrosis
Joint Authors
Di Gioia, Sante
Castellani, Stefano
di Toma, Lorena
Conese, Massimo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-15
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Chronic inflammation, oxidative stress, mucus plugging, airway remodeling, and respiratory infections are the hallmarks of the cystic fibrosis (CF) lung disease.
The airway epithelium is central in the innate immune responses to pathogens colonizing the airways, since it is involved in mucociliary clearance, senses the presence of pathogens, elicits an inflammatory response, orchestrates adaptive immunity, and activates mesenchymal cells.
In this review, we focus on cellular models of the human CF airway epithelium that have been used for studying mucus production, inflammatory response, and airway remodeling, with particular reference to two- and three-dimensional cultures that better recapitulate the native airway epithelium.
Cocultures of airway epithelial cells, macrophages, dendritic cells, and fibroblasts are instrumental in disease modeling, drug discovery, and identification of novel therapeutic targets.
Nevertheless, they have to be implemented in the CF field yet.
Finally, novel systems hijacking on tissue engineering, including three-dimensional cocultures, decellularized lungs, microfluidic devices, and lung organoids formed in bioreactors, will lead the generation of relevant human preclinical respiratory models a step forward.
American Psychological Association (APA)
Castellani, Stefano& Di Gioia, Sante& di Toma, Lorena& Conese, Massimo. 2018. Human Cellular Models for the Investigation of Lung Inflammation and Mucus Production in Cystic Fibrosis. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1117457
Modern Language Association (MLA)
Castellani, Stefano…[et al.]. Human Cellular Models for the Investigation of Lung Inflammation and Mucus Production in Cystic Fibrosis. Analytical Cellular Pathology No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1117457
American Medical Association (AMA)
Castellani, Stefano& Di Gioia, Sante& di Toma, Lorena& Conese, Massimo. Human Cellular Models for the Investigation of Lung Inflammation and Mucus Production in Cystic Fibrosis. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1117457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117457