Insights into the Biology and Therapeutic Applications of Neural Stem Cells
Joint Authors
Harris, Lachlan
Zalucki, Oressia
Piper, Michael
Heng, Julian Ik-Tsen
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
18
Abstract EN
The cerebral cortex is essential for our higher cognitive functions and emotional reasoning.
Arguably, this brain structure is the distinguishing feature of our species, and yet our remarkable cognitive capacity has seemingly come at a cost to the regenerative capacity of the human brain.
Indeed, the capacity for regeneration and neurogenesis of the brains of vertebrates has declined over the course of evolution, from fish to rodents to primates.
Nevertheless, recent evidence supporting the existence of neural stem cells (NSCs) in the adult human brain raises new questions about the biological significance of adult neurogenesis in relation to ageing and the possibility that such endogenous sources of NSCs might provide therapeutic options for the treatment of brain injury and disease.
Here, we highlight recent insights and perspectives on NSCs within both the developing and adult cerebral cortex.
Our review of NSCs during development focuses upon the diversity and therapeutic potential of these cells for use in cellular transplantation and in the modeling of neurodevelopmental disorders.
Finally, we describe the cellular and molecular characteristics of NSCs within the adult brain and strategies to harness the therapeutic potential of these cell populations in the treatment of brain injury and disease.
American Psychological Association (APA)
Harris, Lachlan& Zalucki, Oressia& Piper, Michael& Heng, Julian Ik-Tsen. 2016. Insights into the Biology and Therapeutic Applications of Neural Stem Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1117465
Modern Language Association (MLA)
Harris, Lachlan…[et al.]. Insights into the Biology and Therapeutic Applications of Neural Stem Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-18.
https://search.emarefa.net/detail/BIM-1117465
American Medical Association (AMA)
Harris, Lachlan& Zalucki, Oressia& Piper, Michael& Heng, Julian Ik-Tsen. Insights into the Biology and Therapeutic Applications of Neural Stem Cells. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1117465
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117465