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Endothelial Plasticity: Shifting Phenotypes through Force Feedback
Joint Authors
Krieger, José Eduardo
Krenning, Guido
Harmsen, Martin C.
Moonen, Jan-Renier A. J.
Barauna, Valerio Garrone
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-24
Country of Publication
Egypt
No. of Pages
15
Abstract EN
The endothelial lining of the vasculature is exposed to a large variety of biochemical and hemodynamic stimuli with different gradients throughout the vascular network.
Adequate adaptation requires endothelial cells to be highly plastic, which is reflected by the remarkable heterogeneity of endothelial cells in tissues and organs.
Hemodynamic forces such as fluid shear stress and cyclic strain are strong modulators of the endothelial phenotype and function.
Although endothelial plasticity is essential during development and adult physiology, proatherogenic stimuli can induce adverse plasticity which contributes to disease.
Endothelial-to-mesenchymal transition (EndMT), the hallmark of endothelial plasticity, was long thought to be restricted to embryonic development but has emerged as a pathologic process in a plethora of diseases.
In this perspective we argue how shear stress and cyclic strain can modulate EndMT and discuss how this is reflected in atherosclerosis and pulmonary arterial hypertension.
American Psychological Association (APA)
Krenning, Guido& Barauna, Valerio Garrone& Krieger, José Eduardo& Harmsen, Martin C.& Moonen, Jan-Renier A. J.. 2016. Endothelial Plasticity: Shifting Phenotypes through Force Feedback. Stem Cells International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1117475
Modern Language Association (MLA)
Krenning, Guido…[et al.]. Endothelial Plasticity: Shifting Phenotypes through Force Feedback. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1117475
American Medical Association (AMA)
Krenning, Guido& Barauna, Valerio Garrone& Krieger, José Eduardo& Harmsen, Martin C.& Moonen, Jan-Renier A. J.. Endothelial Plasticity: Shifting Phenotypes through Force Feedback. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1117475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117475