Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation
Joint Authors
Jurišić, Vladimir
Obradovic, Jasmina
Pavlović, Sonja
Djordjevic, Nataša
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recently, epidermal growth factor receptor (EGFR) was a key molecule in investigation of lung cancer, and it was a target for a new therapeutic strategy, based on molecular analyses.
In this review, we have summarized some issues considering the role of EGFR in lung cancer, its coding gene, and its promoter gene polymorphisms (SNPs) -216G/T and -191C/A in non-small-cell lung cancer (NSCLC).
The position of the SNPs indicates their significant role in EGFR regulation.
The accumulation of knowledge regarding SNPs lately suggests their significant and important role in the onset of carcinogenesis, the prediction of the onset of metastases, the response to therapy with TKI inhibitors, and the onset of toxic effects of the applied therapy.
Based on this, we suggest further studies of the relationship of clinical significance to SNPs in patients with lung tumors.
American Psychological Association (APA)
Jurišić, Vladimir& Obradovic, Jasmina& Pavlović, Sonja& Djordjevic, Nataša. 2018. Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117476
Modern Language Association (MLA)
Jurišić, Vladimir…[et al.]. Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation. Analytical Cellular Pathology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1117476
American Medical Association (AMA)
Jurišić, Vladimir& Obradovic, Jasmina& Pavlović, Sonja& Djordjevic, Nataša. Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117476
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117476