![](/images/graphics-bg.png)
Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies
Joint Authors
Tassignon, Marie-José
Haagdorens, Michel
Van Acker, Sara Ilse
Van Gerwen, Veerle
Ní Dhubhghaill, Sorcha
Koppen, Carina
Zakaria, Nadia
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-14
Country of Publication
Egypt
No. of Pages
22
Abstract EN
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain.
To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed.
In recent years, the risk of secondary LSCD due to removal of large limbal grafts has been significantly reduced by the optimization of cultivated limbal epithelial transplantation (CLET).
Despite the great successes of CLET, there still is room for improvement as overall success rate is 70% and visual acuity often remains suboptimal after successful transplantation.
Simple limbal epithelial transplantation reports higher success rates but has not been performed in as many patients yet.
This review focuses on limbal epithelial stem cells and the pathophysiology of LSCD.
State-of-the-art therapeutic management of LSCD is described, and new and evolving techniques in ocular surface regeneration are being discussed, in particular, advantages and disadvantages of alternative cell scaffolds and cell sources for cell based ocular surface reconstruction.
American Psychological Association (APA)
Haagdorens, Michel& Van Acker, Sara Ilse& Van Gerwen, Veerle& Ní Dhubhghaill, Sorcha& Koppen, Carina& Tassignon, Marie-José…[et al.]. 2015. Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies. Stem Cells International،Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1117480
Modern Language Association (MLA)
Haagdorens, Michel…[et al.]. Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-22.
https://search.emarefa.net/detail/BIM-1117480
American Medical Association (AMA)
Haagdorens, Michel& Van Acker, Sara Ilse& Van Gerwen, Veerle& Ní Dhubhghaill, Sorcha& Koppen, Carina& Tassignon, Marie-José…[et al.]. Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-22.
https://search.emarefa.net/detail/BIM-1117480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117480