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Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas
Joint Authors
Warnakulasuriya, Saman
Diniz-Freitas, Márcio
Garcia-Caballero, Tomás
Forteza-Vila, Jerónimo
Fraga, Máximo
Monteiro, Luís Silva
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We analysed the expression of cyclins A2, B1, D1, and E1 by immunohistochemistry and numerical aberrations in CCND1 gene by fluorescence in situ hybridization technique in 67 primary oral squamous cell carcinomas (OSCC).
Cyclin A2 expression was observed in 54 (83.1%) tumours, cyclin D1 in 58 (89.2%), cyclin B1 in 39 (60%), and cyclin E in 21 (32.8%).
CCND1 region analysis revealed 26 (43.3%) tumours with the presence of numerical aberrations which were correlated with cyclin D1 high expression (Rho = 0.48; p<0.001).
Twenty-nine (45.3%) tumours were classified as high proliferative tumours assessed by Ki-67 protein expression and correlated with tumours with high expression of cyclin A2 (Rho = 0.30; p=0.016) and cyclin B1 (Rho = 0.37; p=0.003).
In multivariate analysis for an overall five-year survival (OS), we found an adverse independent prognostic value for cyclin A2 high expression (p=0.031) and for advanced tumour stage (p<0.001).
Our results confirm that several cyclins are commonly expressed in OSCC.
CCND1 gene is abnormal in more than one-third of the cases and is frequently associated with cyclin D1 high expression.
Moreover, cyclin A2 high expression is an independent indicator of worse OS suggesting that this protein may serve as a reliable biological marker to identify high-risk subgroups with poor prognosis.
American Psychological Association (APA)
Monteiro, Luís Silva& Diniz-Freitas, Márcio& Warnakulasuriya, Saman& Garcia-Caballero, Tomás& Forteza-Vila, Jerónimo& Fraga, Máximo. 2018. Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1117499
Modern Language Association (MLA)
Monteiro, Luís Silva…[et al.]. Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas. Analytical Cellular Pathology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1117499
American Medical Association (AMA)
Monteiro, Luís Silva& Diniz-Freitas, Márcio& Warnakulasuriya, Saman& Garcia-Caballero, Tomás& Forteza-Vila, Jerónimo& Fraga, Máximo. Prognostic Significance of Cyclins A2, B1, D1, and E1 and CCND1 Numerical Aberrations in Oral Squamous Cell Carcinomas. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1117499
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117499