Assessment of the Potential Biological Activity of Low Molecular Weight Metabolites of Freshwater Macrophytes with QSAR

Joint Authors

Kurashov, Evgeny A.
Fedorova, Elena V.
Krylova, Julia V.
Mitrukova, Galina G.

Source

Scientifica

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-04-20

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Diseases

Abstract EN

The paper focuses on the assessment of the spectrum of biological activities (antineoplastic, anti-inflammatory, antifungal, and antibacterial) with PASS (Prediction of Activity Spectra for Substances) for the major components of three macrophytes widespread in the Holarctic species of freshwater, emergent macrophyte with floating leaves, Nuphar lutea (L.) Sm., and two species of submergent macrophyte groups, Ceratophyllum demersum L.

and Potamogeton obtusifolius (Mert.

et Koch), for the discovery of their ecological and pharmacological potential.

The predicted probability of anti-inflammatory or antineoplastic activities above 0.8 was observed for twenty compounds.

The same compounds were also characterized by high probability of antifungal and antibacterial activity.

Six metabolites, namely, hexanal, pentadecanal, tetradecanoic acid, dibutyl phthalate, hexadecanoic acid, and manool, were a part of the major components of all three studied plants, indicating their high ecological significance and a certain universalism in their use by various species of water plants for the implementation of ecological and biochemical functions.

This report underlines the role of identified compounds not only as important components in regulation of biochemical and metabolic pathways and processes in aquatic ecological systems, but also as potential pharmacological agents in the fight against different diseases.

American Psychological Association (APA)

Kurashov, Evgeny A.& Fedorova, Elena V.& Krylova, Julia V.& Mitrukova, Galina G.. 2016. Assessment of the Potential Biological Activity of Low Molecular Weight Metabolites of Freshwater Macrophytes with QSAR. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117523

Modern Language Association (MLA)

Kurashov, Evgeny A.…[et al.]. Assessment of the Potential Biological Activity of Low Molecular Weight Metabolites of Freshwater Macrophytes with QSAR. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117523

American Medical Association (AMA)

Kurashov, Evgeny A.& Fedorova, Elena V.& Krylova, Julia V.& Mitrukova, Galina G.. Assessment of the Potential Biological Activity of Low Molecular Weight Metabolites of Freshwater Macrophytes with QSAR. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117523

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1117523