Heparan Sulfate Proteoglycans in Human Colorectal Cancer
Joint Authors
Vicente, Carolina Meloni
da Silva, Daiana Aparecida
Sartorio, Priscila Veronica
Silva, Tiago Donizetti
Saad, Sarhan Sydney
Forones, Nora Manoukian
Toma, Leny
Nader, Helena Bonciani
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Colorectal cancer is the third most common cancer worldwide, accounting for more than 610,000 mortalities every year.
Prognosis of patients is highly dependent on the disease stage at diagnosis.
Therefore, it is crucial to investigate molecules involved in colorectal cancer tumorigenesis, with possible use as tumor markers.
Heparan sulfate proteoglycans are complex molecules present in the cell membrane and extracellular matrix, which play vital roles in cell adhesion, migration, proliferation, and signaling pathways.
In colorectal cancer, the cell surface proteoglycan syndecan-2 is upregulated and increases cell migration.
Moreover, expression of syndecan-1 and syndecan-4, generally antitumor molecules, is reduced.
Levels of glypicans and perlecan are also altered in colorectal cancer; however, their role in tumor progression is not fully understood.
In addition, studies have reported increased heparan sulfate remodeling enzymes, as the endosulfatases.
Therefore, heparan sulfate proteoglycans are candidate molecules to clarify colorectal cancer tumorigenesis, as well as important targets to therapy and diagnosis.
American Psychological Association (APA)
Vicente, Carolina Meloni& da Silva, Daiana Aparecida& Sartorio, Priscila Veronica& Silva, Tiago Donizetti& Saad, Sarhan Sydney& Nader, Helena Bonciani…[et al.]. 2018. Heparan Sulfate Proteoglycans in Human Colorectal Cancer. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1117535
Modern Language Association (MLA)
Vicente, Carolina Meloni…[et al.]. Heparan Sulfate Proteoglycans in Human Colorectal Cancer. Analytical Cellular Pathology No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1117535
American Medical Association (AMA)
Vicente, Carolina Meloni& da Silva, Daiana Aparecida& Sartorio, Priscila Veronica& Silva, Tiago Donizetti& Saad, Sarhan Sydney& Nader, Helena Bonciani…[et al.]. Heparan Sulfate Proteoglycans in Human Colorectal Cancer. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1117535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117535