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MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration
Joint Authors
Zhang, Bo
Li, Yali
Yu, Yang
Zhao, Jinlong
Ou, Yangzhen
Chao, Yu
Yang, Binhui
Yu, Xiaorui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bone tissue regeneration was closely associated with osteogenesis and angiogenesis.
The harmonious regulation of osteogenetic and angiogenic growth factors would enhance bone regeneration, while the imbalance of that would lead to local excessive bone formation or vascular mass due to exogenous delivery.
Therefore, microRNA is believed to regulate multiple metabolism progress through endogenous signaling pathways on the gene level.
In this work, we identified microRNA 378 as a positive regulator of osteogenesis and angiogenesis simultaneously and also observed an increase of microRNA 378 than control in human bone marrow mesenchymal stem cells (hBMMSCs) after osteoblast induction.
Besides, osteogenetic and angiogenic gene expression increased simultaneously after overexpression of microRNA 378.
Moreover, alizarin red staining and alkaline phosphatase (ALP) staining enhanced, and secretion of vascular endothelial growth factor (VEGF) increased.
In this way, we believed miR378 was an ideal target to osteogenesis-angiogenesis coupling for bone regeneration, which provides a potential tool for the gene therapy of bone regeneration.
American Psychological Association (APA)
Zhang, Bo& Li, Yali& Yu, Yang& Zhao, Jinlong& Ou, Yangzhen& Chao, Yu…[et al.]. 2018. MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117540
Modern Language Association (MLA)
Zhang, Bo…[et al.]. MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration. Analytical Cellular Pathology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1117540
American Medical Association (AMA)
Zhang, Bo& Li, Yali& Yu, Yang& Zhao, Jinlong& Ou, Yangzhen& Chao, Yu…[et al.]. MicroRNA-378 Promotes Osteogenesis-Angiogenesis Coupling in BMMSCs for Potential Bone Regeneration. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1117540
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117540