Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury
Joint Authors
Chakraborty, Anubhav
Viswanathan, Pragasam
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-08
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Over the years, the epigenetic landscape has grown increasingly complex.
Until recently, methylation of DNA and histones was considered one of the most important epigenetic modifications.
However, with the discovery of enzymes involved in the demethylation process, several exciting prospects have emerged that focus on the dynamic regulation of methylation and its crucial role in development and disease.
An interplay of the methylation-demethylation machinery controls the process of gene expression.
Since acute kidney injury (AKI), a major risk factor for chronic kidney disease and death, is characterised by aberrant expression of genes, understanding the dynamics of methylation and demethylation will provide new insights into the intricacies of the disease.
Research on epigenetics in AKI has only made its mark in the recent years but has provided compelling evidence that implicates the involvement of methylation and demethylation changes in its pathophysiology.
In this review, we explore the role of methylation and demethylation machinery in cellular epigenetic control and further discuss the contribution of methylomic changes and histone modifications to the pathophysiology of AKI.
American Psychological Association (APA)
Chakraborty, Anubhav& Viswanathan, Pragasam. 2018. Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury. Analytical Cellular Pathology،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1117559
Modern Language Association (MLA)
Chakraborty, Anubhav& Viswanathan, Pragasam. Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury. Analytical Cellular Pathology No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1117559
American Medical Association (AMA)
Chakraborty, Anubhav& Viswanathan, Pragasam. Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury. Analytical Cellular Pathology. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1117559
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117559