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Safety Evaluation of Unani Formulation: Capsule Shaqeeqa in Albino Wistar Rats
Joint Authors
Akbar, Seema
Nazir, Tazeen
Hamdani, Mariya
Siddiqui, Khalid M.
Kumar, Pawan
Masood, Akbar
Ghazanfar, Khalid
Dar, Showkat Ahmad
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Capsule Shaqeeqa, Unani formulation, is prescribed for the clinical treatment of diseases like sinusitis, headache, and migraine.
The safety evaluation data of it is not available; in order to provide the safety data the present study was carried out.
The study was carried out on four groups of rats (n=5).
Two groups (one male and one female group) as normal controls were orally given water while the other two groups were orally given daily doses of drug at the dose level of 150 mg/kg of body weight for duration of 90 days.
Physiological parameters like body weight, feed consumption, water consumption, and clinical signs were regularly monitored and recorded.
Organs were collected, examined, and weighed and specimens were taken for histopathological studies.
The results showed that the drug did not alter the physiological parameters.
There was no mortality or any morbidity found in drug treated rats.
There was no statistical significant change found in any haematological or biochemical parameter of rats orally fed with Shaqeeqa.
A statistically insignificant association verified that haematological and biochemical parameters were rendered unaffected by the drug.
Moreover histological investigations of essential key organs demonstrated that the drug did not prompt any histopathological change.
These observations demonstrate the safety of Capsule Shaqeeqa at the studied dosage levels.
American Psychological Association (APA)
Ghazanfar, Khalid& Dar, Showkat Ahmad& Akbar, Seema& Nazir, Tazeen& Hamdani, Mariya& Siddiqui, Khalid M.…[et al.]. 2016. Safety Evaluation of Unani Formulation: Capsule Shaqeeqa in Albino Wistar Rats. Scientifica،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117581
Modern Language Association (MLA)
Ghazanfar, Khalid…[et al.]. Safety Evaluation of Unani Formulation: Capsule Shaqeeqa in Albino Wistar Rats. Scientifica No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1117581
American Medical Association (AMA)
Ghazanfar, Khalid& Dar, Showkat Ahmad& Akbar, Seema& Nazir, Tazeen& Hamdani, Mariya& Siddiqui, Khalid M.…[et al.]. Safety Evaluation of Unani Formulation: Capsule Shaqeeqa in Albino Wistar Rats. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117581
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117581