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The Importance of Risk and Subgroup Analysis of Nonparticipants in a Geriatric Intervention Study
Joint Authors
Wagner, Lis
Poulsen, Ingrid
Rosted, Elizabeth
Hendriksen, Carsten
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
A major concern in intervention studies is the generalizability of the findings due to refusal of intended participants to actually take part.
In studies including ill older people the number of those declining to participate may be large and the concern is therefore relevant.
Objectives.
To compare patients characteristics, rates of acute readmission, and mortality after one and six months among older persons who agreed and those who declined to participate in a randomized controlled trial and to describe subgroups of nonparticipants.
Design.
Comparative study based on a randomized controlled trial.
Setting.
University hospital in the Capital Region of Denmark.
Participants.
Patients ≥70 years discharged home after a short Emergency Department stay.
399 were requested to participate; 271 consented, whereas 128 refused.
Results.
Refusers were more likely to be readmitted ( p < 0.001 ) or die ( p = 0.006 ).
The largest subgroup of refusers described as “too ill” had the highest risk of readmission (OR = 3.00, 95% CI = 1.61–5.47, p = 0.001 ) and of mortality within six months (OR = 3.50, 95% CI = 1.64–7.49, p = 0.002 ).
However, this seems not to have affected the results of our randomized study.
Conclusion.
We recommend that intervention studies among older people or other fragile patient groups include analysis of relevant risk and subgroup analyses of refusers.
American Psychological Association (APA)
Rosted, Elizabeth& Poulsen, Ingrid& Hendriksen, Carsten& Wagner, Lis. 2016. The Importance of Risk and Subgroup Analysis of Nonparticipants in a Geriatric Intervention Study. Scientifica،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117590
Modern Language Association (MLA)
Rosted, Elizabeth…[et al.]. The Importance of Risk and Subgroup Analysis of Nonparticipants in a Geriatric Intervention Study. Scientifica No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1117590
American Medical Association (AMA)
Rosted, Elizabeth& Poulsen, Ingrid& Hendriksen, Carsten& Wagner, Lis. The Importance of Risk and Subgroup Analysis of Nonparticipants in a Geriatric Intervention Study. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117590