Differences in E-Cadherin and Syndecan-1 Expression in Different Types of Ameloblastomas

Abstract EN

Ameloblastomas are a group of benign, locally aggressive, recurrent tumors characterized by their slow and infiltrative growth.

E-Cadherin and syndecan-1 are cell adhesion molecules related to the behavior of various tumors, including ameloblastomas.

Ninety-nine ameloblastoma samples were studied; the expression of E-cadherin and syndecan-1 were evaluated by immunohistochemistry.

E-Cadherin and epithelial syndecan-1 were more highly expressed in intraluminal/luminal unicystic ameloblastoma than in mural unicystic ameloblastoma and solid/multicystic ameloblastoma, whereas the stromal expression of syndecan-1 was higher in mural unicystic ameloblastoma and solid/multicystic ameloblastoma.

Synchronicity was observed between E-cadherin and epithelial syndecan-1; the expression was correlated with intensity in all cases.

There was a strong association between expression and tumor size and recurrence.

The evaluation of the expression of E-cadherin and syndecan-1 are important for determining the potential aggressiveness of ameloblastoma variants.

Future studies are required to understand how the expression of these markers is related to tumor aggressiveness.