In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase
Joint Authors
Fernández-Fernández, Álvaro D.
Corpas, Francisco J.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
NADPH, whose regeneration is critical for reductive biosynthesis and detoxification pathways, is an essential component in cell redox homeostasis.
Peroxisomes are subcellular organelles with a complex biochemical machinery involved in signaling and stress processes by molecules such as hydrogen peroxide (H2O2) and nitric oxide (NO).
NADPH is required by several peroxisomal enzymes involved in β-oxidation, NO, and glutathione (GSH) generation.
Plants have various NADPH-generating dehydrogenases, one of which is 6-phosphogluconate dehydrogenase (6PGDH).
Arabidopsis contains three 6PGDH genes that probably are encoded for cytosolic, chloroplastic/mitochondrial, and peroxisomal isozymes, although their specific functions remain largely unknown.
This study focuses on the in silico analysis of the biochemical characteristics and gene expression of peroxisomal 6PGDH (p6PGDH) with the aim of understanding its potential function in the peroxisomal NADPH-recycling system.
The data show that a group of plant 6PGDHs contains an archetypal type 1 peroxisomal targeting signal (PTS), while in silico gene expression analysis using affymetrix microarray data suggests that Arabidopsis p6PGDH appears to be mainly involved in xenobiotic response, growth, and developmental processes.
American Psychological Association (APA)
Fernández-Fernández, Álvaro D.& Corpas, Francisco J.. 2016. In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase. Scientifica،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117624
Modern Language Association (MLA)
Fernández-Fernández, Álvaro D.& Corpas, Francisco J.. In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase. Scientifica No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1117624
American Medical Association (AMA)
Fernández-Fernández, Álvaro D.& Corpas, Francisco J.. In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase. Scientifica. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1117624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1117624